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pentobarbital will lower the level or influence of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to a lessen in fentanyl plasma concentrations, lack of efficacy or, probably, enhancement of a withdrawal syndrome within a affected individua

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